Connection NOT persisting

When connecting to my couchbase cluster I seem to be able to make request successfully for a few minutes and then all request begin to fail with the following:

getMulti Error:
{ [Error: At least one of your operations failed, check the results object for more information.] code: 4101 }

get:
Fails with a code 23

Isn’t the connection meant to be persistent? I noticed in documentation for other sdks (PHP I believe) the ability to pass in a true or false for persistent connection. The Node connection however does not appear to take this argument.

Any help would be great!
-Ryan

Hey did you found any solution?
I am getting same error when using getMulti.
I have found that when the response size is large, getMulti throws this error

It gives Network error code: 16
{ [Error: At least one of your operations failed, check the results object for more information.] code: 4101 }

Any help would be highly appreciated.
Thanks

Regards
team.avesta