Assume we can have enough RAM/CPU/network bandwidth, my answer would be yes.
On a separate, on Couchbase 4.0, we introduced global secondary index and N1QL.
Based on your use case, it seems to be a good fit to take advantage of these two features.
Doc here:
http://docs.couchbase.com/4.0/indexes/query-intro.html
http://docs.couchbase.com/4.0/n1ql/index.html
Thanks,
Qi